The Silence of The Lambs is considered by many to be one of the greatest horror films of all time. The psychological thriller starring Anthony Hopkins, Ted Levine and Jodie Foster crushed at the box office and the 64th Academy Awards, ultimately taking home five Oscars. Despite Jodie Foster earning her second Academy Award at just 28, the role of FBI agent Clarice Starling was originally intended for Michele Pfeiffer, who, in a recent interview, shared her biggest regret from turning down The Silence of The Lambs.

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